UK - Lab Grown Esophagus Implanted in Mice

Arno Froese

Scientists in London have grown a bio-engineered esophagus which was successfully implanted into mice.

The work, published in Nature Communications, was led by scientists at UCL Great Ormond Street Institute of Child Health (ICH), Great Ormond Street Hospital (GOSH) and the Francis Crick Institute.

The esophagus is a complex, multi-layered organ, made up of multiple tissue types, which acts as a pipe carrying food and liquid from the mouth to the stomach.

They seeded it with early-stage muscle and connective tissue from mice and humans, and other early rat cells which went on to form the lining on the inside of the organ.

The use of stem cells from different species enabled researchers to differentiate between the origin of each tissue type which developed.

Dr. Paola Bonfanti, co-author and group leader at the Francis Crick Institute and UCL Great Ormond Street Hospital Institute of Child Health (ICH), said: “We were amazed to see that our engineered tissue had both the structure and function of a healthy esophagus, and hooked up with nearby blood vessels within a week of transplantation.”

Prof. Paolo De Coppi, co-author and consultant surgeon at Gosh, and head of stem cells and regenerative medicine at ICH, said: “This is a major step forward for regenerative medicine, bringing us ever closer to treatment that goes beyond repairing damaged tissue and offers the possibility of rejection-free organs and tissues for transplant.”

The eventual aim would be to create bio-engineered organs from a pig esophagus, which would be injected with a patient’s own stem cells, in order to minimize the risk of rejection.

The field of engineered organ transplants suffered a major setback in 2016 when a surgeon in Sweden, Paolo Macchiarini, was accused of falsifying his science.

Of nine patients who received a synthetic windpipe, seven died, and the two survivors had the organ replaced with a donor trachea.

The team at the Crick and Gosh say the scandal reinforced their determination to proceed cautiously., 16 October 2018

Arno's commentary

Medical science seems to create the impossible: a functioning lab-generated organ, although the word “create” is exaggerated. Man can change created tissue from an existing animal in this case, making it rightly called “engineered tissue.” Nevertheless, there is no end in sight of man manipulating the genes of animals for the benefit of humans.

While it is difficult to say where the red line lies in such sophisticated science, we do recognize the tendency: man can do “everything.” That means he will be increasingly independent from the Creator. Subsequently, we see religion, particularly Churchianity, losing its hold on the population in general, and particularly in the most successful countries. As one other resource states: “the less religion, the more prosperity.”

Arno Froese is the executive director of Midnight Call Ministries and editor-in-chief of the acclaimed prophetic magazines Midnight Call and News From Israel. He has authored a number of well-received books, and has sponsored many prophecy conferences in the U.S., Canada, and Israel. His extensive travels have contributed to his keen insight into Bible prophecy, as he sees it from an international perspective.

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